LCN2 (lipocalin 2)

2003-11-01  

Identity

HGNC
LCN2
LOCATION
9q34.11
LOCUSID
3934
ALIAS
24p3,MSFI,NGAL,p25
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3934
MIM: 600181
HGNC: 6526
Ensembl: ENSG00000148346

Variants:

dbSNP: 3934
ClinVar: 3934
TCGA: ENSG00000148346
COSMIC: LCN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148346ENST00000277480P80188
ENSG00000148346ENST00000372998X6R8F3
ENSG00000148346ENST00000373017P80188

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
Antimicrobial peptidesREACTOMER-HSA-6803157
Metal sequestration by antimicrobial proteinsREACTOMER-HSA-6799990
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198503882009Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis.315
157116402005Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury.277
172299072007Dual action of neutrophil gelatinase-associated lipocalin.208
183375542008Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study.200
218361432011Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery.186
215111112011The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies.179
191767952009Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease.146
168278652006Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation.132
180703442007Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study.127
167987342006Identification of common transcriptional regulatory elements in interleukin-17 target genes.121

Citation

Dessen P

LCN2 (lipocalin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41133/lcn2