LCN2 (lipocalin 2)

2003-11-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
24p3,MSFI,NGAL,p25
FUSION GENES

Other Information

Locus ID:

NCBI: 3934
MIM: 600181
HGNC: 6526
Ensembl: ENSG00000148346

Variants:

dbSNP: 3934
ClinVar: 3934
TCGA: ENSG00000148346
COSMIC: LCN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148346ENST00000277480P80188
ENSG00000148346ENST00000372998X6R8F3
ENSG00000148346ENST00000373017P80188

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
Antimicrobial peptidesREACTOMER-HSA-6803157
Metal sequestration by antimicrobial proteinsREACTOMER-HSA-6799990
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371782512024LCN2 Promotes Proliferation and Glycolysis by Activating the JAK2/STAT3 Signaling Pathway in Hepatocellular Carcinoma.0
375167062024Urinary neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1) as markers of active lupus nephritis.0
375678322024Lipocalin-2 promotes neutrophilic inflammation in nasal polyps and its value as biomarker.0
377211222024Tumor-associated astrocytes promote tumor progression of Sonic Hedgehog medulloblastoma by secreting lipocalin-2.1
379429292024Plasma neutrophil gelatinase-associated lipocalin predicts renal tubulointerstitial injury in patients with IgA nephropathy.0
379954972024Neutrophil gelatinase-associated lipocalin (NGAL) and inflammatory markers in schizophrenia: A comparative analysis of drug-naive schizophrenia patients, remitted patients, and healthy controls.0
380007022024Inhibiting LCN2 can suppress the development of NSCLC by promoting ferroptosis.0
380721182024Quantitative Proteomics of Tissue-Infiltrating T Cells From CRC Patients Identified Lipocalin-2 Induces T-Cell Apoptosis and Promotes Tumor Cell Proliferation by Iron Efflux.0
381712482024LCN2: Versatile players in breast cancer.1
382386532024Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension.1
382959162024Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.0
383968902024Serum Lipocalin-2 Levels as a Biomarker in Pre- and Post-Pubertal Klinefelter Syndrome Patients: A Pilot Study.1
385422012024Neutrophil Gelatinase-Associated Lipocalin for the Differentiation of Mucinous Pancreatic Cystic Lesions.0
371782512024LCN2 Promotes Proliferation and Glycolysis by Activating the JAK2/STAT3 Signaling Pathway in Hepatocellular Carcinoma.0
375167062024Urinary neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1) as markers of active lupus nephritis.0

Citation

Dessen P

LCN2 (lipocalin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41133/lcn2