LCP2 (lymphocyte cytosolic protein 2)

2007-02-01  

Identity

HGNC
LOCATION
5q35.1
LOCUSID
ALIAS
SLP-76,SLP76
FUSION GENES

Other Information

Locus ID:

NCBI: 3937
MIM: 601603
HGNC: 6529
Ensembl: ENSG00000043462

Variants:

dbSNP: 3937
ClinVar: 3937
TCGA: ENSG00000043462
COSMIC: LCP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000043462ENST00000046794Q13094
ENSG00000043462ENST00000520344E5RKA2
ENSG00000043462ENST00000521416E7ESF6
ENSG00000043462ENST00000628092A0A0D9SGG1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
T cell receptor signaling pathwayKEGGko04660
Fc epsilon RI signaling pathwayKEGGko04664
Natural killer cell mediated cytotoxicityKEGGhsa04650
T cell receptor signaling pathwayKEGGhsa04660
Fc epsilon RI signaling pathwayKEGGhsa04664
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185498002008T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76.71
205628272010Cooperative interactions at the SLP-76 complex are critical for actin polymerization.56
128472552003Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization.47
169147522006CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.44
174204792007SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.43
196670772009The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.40
147220892004Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.33
156990712005The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation.32
171484602007Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1.23
227867242012Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells.23

Citation

Dessen P

LCP2 (lymphocyte cytosolic protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45540/lcp2