Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 197257
MIM: 607490
HGNC: 19708
Ensembl: ENSG00000166816
Variants:
dbSNP: 197257
ClinVar: 197257
TCGA: ENSG00000166816
COSMIC: LDHD
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166816 | ENST00000300051 | Q86WU2 |
| ENSG00000166816 | ENST00000450168 | Q86WU2 |
| ENSG00000166816 | ENST00000569876 | H3BM70 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Pyruvate metabolism | KEGG | ko00620 |
| Pyruvate metabolism | KEGG | hsa00620 |
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Mitochondrial protein import | REACTOME | R-HSA-1268020 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38291366 | 2024 | Systematic analysis of the role of LDHs subtype in pan-cancer demonstrates the importance of LDHD in the prognosis of hepatocellular carcinoma patients. | 1 |
| 38291366 | 2024 | Systematic analysis of the role of LDHs subtype in pan-cancer demonstrates the importance of LDHD in the prognosis of hepatocellular carcinoma patients. | 1 |
| 37021930 | 2023 | Early-onset gout and rare deficient variants of the lactate dehydrogenase D gene. | 0 |
| 37021930 | 2023 | Early-onset gout and rare deficient variants of the lactate dehydrogenase D gene. | 0 |
| 33301764 | 2021 | Cancer/testis antigen LDHC promotes proliferation and metastasis by activating the PI3K/Akt/GSK-3β-signaling pathway and the in lung adenocarcinoma. | 22 |
| 33301764 | 2021 | Cancer/testis antigen LDHC promotes proliferation and metastasis by activating the PI3K/Akt/GSK-3β-signaling pathway and the in lung adenocarcinoma. | 22 |
| 31638601 | 2019 | Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase. | 13 |
| 31638601 | 2019 | Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase. | 13 |
| 23333299 | 2013 | Prostate cancer cells metabolize d-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. | 18 |
| 23333299 | 2013 | Prostate cancer cells metabolize d-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. | 18 |
| 19844255 | 2010 | Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. | 10 |
| 20499337 | 2010 | Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders. | 13 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 19844255 | 2010 | Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. | 10 |
| 20499337 | 2010 | Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders. | 13 |
Citation
Dessen P
LDHD (lactate dehydrogenase D)
Atlas Genet Cytogenet Oncol Haematol. 2013-05-01
Online version: http://atlasgeneticsoncology.org/gene/53268/ldhd
