LGALS1 (galectin 1)

2007-02-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
GAL1,GBP
FUSION GENES

Other Information

Locus ID:

NCBI: 3956
MIM: 150570
HGNC: 6561
Ensembl: ENSG00000100097

Variants:

dbSNP: 3956
ClinVar: 3956
TCGA: ENSG00000100097
COSMIC: LGALS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100097ENST00000215909P09382
ENSG00000100097ENST00000215909A0A384MR27
ENSG00000100097ENST00000425542F8WCQ5
ENSG00000100097ENST00000454173F8WEI7

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171104622007Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.135
150509162004Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege.131
170432432006Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.129
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
206441182010Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells.78
182925322008Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion.73
159726752005Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines.63
258195242015Galectin expression in cancer diagnosis and prognosis: A systematic review.61
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
182236832008Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells.57

Citation

Dessen P

LGALS1 (galectin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46326/lgals1