LGALS8 (galectin 8)

2003-02-01  

Identity

HGNC
LOCATION
1q43
LOCUSID
ALIAS
Gal-8,PCTA-1,PCTA1,Po66-CBP
FUSION GENES

Other Information

Locus ID:

NCBI: 3964
MIM: 606099
HGNC: 6569
Ensembl: ENSG00000116977

Variants:

dbSNP: 3964
ClinVar: 3964
TCGA: ENSG00000116977
COSMIC: LGALS8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116977ENST00000238181H7BXD8
ENSG00000116977ENST00000323938E9PN19
ENSG00000116977ENST00000341872O00214
ENSG00000116977ENST00000352231O00214
ENSG00000116977ENST00000366584O00214
ENSG00000116977ENST00000406509Q5T3P9
ENSG00000116977ENST00000416919F6V2D4
ENSG00000116977ENST00000430527E9PRN3
ENSG00000116977ENST00000434231E9PPM4
ENSG00000116977ENST00000442397E9PNC2
ENSG00000116977ENST00000450372O00214
ENSG00000116977ENST00000454943B1ANM0
ENSG00000116977ENST00000481485E9PJ77
ENSG00000116977ENST00000525042F6V2D4
ENSG00000116977ENST00000526589O00214
ENSG00000116977ENST00000526634O00214
ENSG00000116977ENST00000527974O00214
ENSG00000116977ENST00000529489E9PPL1

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222463242012Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion.287
184566652008Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain.53
173392812007Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface.46
128814092003Galectin-8 modulates neutrophil function via interaction with integrin alphaM.36
233867462013Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy.35
212889022011Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans.34
192684622009Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.28
208762112011Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8.28
128512892003The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity.25
270667372016Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.20

Citation

Dessen P

LGALS8 (galectin 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41146/lgals8