LGR4 (leucine rich repeat containing G protein-coupled receptor 4)

2008-07-01  

Identity

HGNC
LGR4
LOCATION
11p14.1
LOCUSID
55366
ALIAS
BNMD17,GPR48
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55366
MIM: 606666
HGNC: 13299
Ensembl: ENSG00000205213

Variants:

dbSNP: 55366
ClinVar: 55366
TCGA: ENSG00000205213
COSMIC: LGR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205213ENST00000379214Q9BXB1
ENSG00000205213ENST00000389858Q9BXB1
ENSG00000205213ENST00000480977E9PK51

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
216936462011R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.276
236444562013Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.88
228158842012R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.69
270644492016LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.55
246395262014RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.33
234443782013Multi-functional norrin is a ligand for the LGR4 receptor.31
171788562006Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.30
242120902013Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.29
255313222015Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.19
238036912013GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.17

Citation

Dessen P

LGR4 (leucine rich repeat containing G protein-coupled receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50275/lgr4