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LILRA2 (leukocyte immunoglobulin like receptor A2)

Identity

Alias_namesleukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
Alias_symbol (synonym)LIR-7
ILT1
CD85h
LIR7
Other aliasCD85H
HGNC (Hugo) LILRA2
LocusID (NCBI) 11027
Atlas_Id 57770
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 54572997 and ends at 54587561 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LILRA2 (19q13.42) / RAB11B (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(18;19)(q21;q13) LILRA2/CCBE1


External links

Nomenclature
HGNC (Hugo)LILRA2   6603
Cards
Entrez_Gene (NCBI)LILRA2  11027  leukocyte immunoglobulin like receptor A2
AliasesCD85H; ILT1; LIR-7; LIR7
GeneCards (Weizmann)LILRA2
Ensembl hg19 (Hinxton)ENSG00000239998 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000239998 [Gene_View]  ENSG00000239998 [Sequence]  chr19:54572997-54587561 [Contig_View]  LILRA2 [Vega]
ICGC DataPortalENSG00000239998
TCGA cBioPortalLILRA2
AceView (NCBI)LILRA2
Genatlas (Paris)LILRA2
WikiGenes11027
SOURCE (Princeton)LILRA2
Genetics Home Reference (NIH)LILRA2
Genomic and cartography
GoldenPath hg38 (UCSC)LILRA2  -     chr19:54572997-54587561 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LILRA2  -     19q13.42   [Description]    (hg19-Feb_2009)
GoldenPathLILRA2 - 19q13.42 [CytoView hg19]  LILRA2 - 19q13.42 [CytoView hg38]
ImmunoBaseENSG00000239998
Mapping of homologs : NCBILILRA2 [Mapview hg19]  LILRA2 [Mapview hg38]
OMIM604812   
Gene and transcription
Genbank (Entrez)AF025531 AK130170 AK222651 AK310088 BC017412
RefSeq transcript (Entrez)NM_001130917 NM_001290270 NM_001290271 NM_006866
RefSeq genomic (Entrez)NC_000019 NG_034038 NT_187693 NW_003571054 NW_003571060
Consensus coding sequences : CCDS (NCBI)LILRA2
Cluster EST : UnigeneHs.739156 [ NCBI ]
CGAP (NCI)Hs.739156
Alternative Splicing GalleryENSG00000239998
Gene ExpressionLILRA2 [ NCBI-GEO ]   LILRA2 [ EBI - ARRAY_EXPRESS ]   LILRA2 [ SEEK ]   LILRA2 [ MEM ]
Gene Expression Viewer (FireBrowse)LILRA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11027
GTEX Portal (Tissue expression)LILRA2
Human Protein AtlasENSG00000239998-LILRA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N149   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N149  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N149
Splice isoforms : SwissVarQ8N149
PhosPhoSitePlusQ8N149
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)A1B_glyco/leuk_Ig-like_rcpt    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_sub2    Immunoglobulin   
Domain families : Pfam (Sanger)ig (PF00047)    Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam00047    pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)LILRA2
DMDM Disease mutations11027
Blocks (Seattle)LILRA2
PDB (RSDB)2OTP   
PDB Europe2OTP   
PDB (PDBSum)2OTP   
PDB (IMB)2OTP   
Structural Biology KnowledgeBase2OTP   
SCOP (Structural Classification of Proteins)2OTP   
CATH (Classification of proteins structures)2OTP   
SuperfamilyQ8N149
Human Protein Atlas [tissue]ENSG00000239998-LILRA2 [tissue]
Peptide AtlasQ8N149
IPIIPI00027972   IPI00157163   IPI00646137   IPI00657726   IPI00916786   
Protein Interaction databases
DIP (DOE-UCLA)Q8N149
IntAct (EBI)Q8N149
FunCoupENSG00000239998
BioGRIDLILRA2
STRING (EMBL)LILRA2
ZODIACLILRA2
Ontologies - Pathways
QuickGOQ8N149
Ontology : AmiGOIgM binding  innate immune response activating cell surface receptor signaling pathway  neutrophil activation involved in immune response  antigen binding  extracellular region  integral component of plasma membrane  defense response  signal transduction  negative regulation of lipopolysaccharide-mediated signaling pathway  granulocyte macrophage colony-stimulating factor production  interleukin-6 production  interleukin-8 production  negative regulation of toll-like receptor 4 signaling pathway  signaling receptor activity  innate immune response  positive regulation of interleukin-1 beta secretion  positive regulation of cell activation  positive regulation of calcium ion transport  granulocyte colony-stimulating factor production  positive regulation of tumor necrosis factor secretion  positive regulation of interleukin-6 secretion  
Ontology : EGO-EBIIgM binding  innate immune response activating cell surface receptor signaling pathway  neutrophil activation involved in immune response  antigen binding  extracellular region  integral component of plasma membrane  defense response  signal transduction  negative regulation of lipopolysaccharide-mediated signaling pathway  granulocyte macrophage colony-stimulating factor production  interleukin-6 production  interleukin-8 production  negative regulation of toll-like receptor 4 signaling pathway  signaling receptor activity  innate immune response  positive regulation of interleukin-1 beta secretion  positive regulation of cell activation  positive regulation of calcium ion transport  granulocyte colony-stimulating factor production  positive regulation of tumor necrosis factor secretion  positive regulation of interleukin-6 secretion  
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkLILRA2
Atlas of Cancer Signalling NetworkLILRA2
Wikipedia pathwaysLILRA2
Orthology - Evolution
OrthoDB11027
GeneTree (enSembl)ENSG00000239998
Phylogenetic Trees/Animal Genes : TreeFamLILRA2
HOGENOMQ8N149
Homologs : HomoloGeneLILRA2
Homology/Alignments : Family Browser (UCSC)LILRA2
Gene fusions - Rearrangements
Fusion : QuiverLILRA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLILRA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LILRA2
dbVarLILRA2
ClinVarLILRA2
1000_GenomesLILRA2 
Exome Variant ServerLILRA2
ExAC (Exome Aggregation Consortium)ENSG00000239998
GNOMAD BrowserENSG00000239998
Varsome BrowserLILRA2
Genetic variants : HAPMAP11027
Genomic Variants (DGV)LILRA2 [DGVbeta]
DECIPHERLILRA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLILRA2 
Mutations
ICGC Data PortalLILRA2 
TCGA Data PortalLILRA2 
Broad Tumor PortalLILRA2
OASIS PortalLILRA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLILRA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLILRA2
Mutations and Diseases : HGMDLILRA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LILRA2
DgiDB (Drug Gene Interaction Database)LILRA2
DoCM (Curated mutations)LILRA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LILRA2 (select a term)
intoGenLILRA2
Cancer3DLILRA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604812   
Orphanet
DisGeNETLILRA2
MedgenLILRA2
Genetic Testing Registry LILRA2
NextProtQ8N149 [Medical]
TSGene11027
GENETestsLILRA2
Target ValidationLILRA2
Huge Navigator LILRA2 [HugePedia]
snp3D : Map Gene to Disease11027
BioCentury BCIQLILRA2
ClinGenLILRA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11027
Chemical/Pharm GKB GenePA30377
Clinical trialLILRA2
Miscellaneous
canSAR (ICR)LILRA2 (select the gene name)
DataMed IndexLILRA2
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLILRA2
EVEXLILRA2
GoPubMedLILRA2
iHOPLILRA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:50:39 CET 2019

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