LILRB1 (leukocyte immunoglobulin like receptor B1)

2010-08-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD85J,ILT-2,ILT2,LIR-1,LIR1,MIR-7,MIR7,PIR-B,PIRB
FUSION GENES

Other Information

Locus ID:

NCBI: 10859
MIM: 604811
HGNC: 6605
Ensembl: ENSG00000104972

Variants:

dbSNP: 10859
ClinVar: 10859
TCGA: ENSG00000104972
COSMIC: LILRB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104972ENST00000324602A0A087WSV6
ENSG00000104972ENST00000396315A0A087WSV6
ENSG00000104972ENST00000396317A8MVE2
ENSG00000104972ENST00000396327A0A087WSX8
ENSG00000104972ENST00000396331A0A0B4J1W1
ENSG00000104972ENST00000396332D9IDM5
ENSG00000104972ENST00000421584F6RVM3
ENSG00000104972ENST00000427581F6TER3

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
128535762003Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.115
250700492014MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.109
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
232084952013microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis.73
156709762005HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.62
193047992009HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.54
212704082011HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.51
189463522008Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr1+ myeloid-derived suppressor cells that promote long-term survival of allografts.43
155858442004Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells.39
186325772008Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor.39

Citation

Dessen P

LILRB1 (leukocyte immunoglobulin like receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51630/lilrb1