LILRB2 (leukocyte immunoglobulin like receptor B2)

2012-08-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD85D,ILT-4,ILT4,LIR-2,LIR2,MIR-10,MIR10

Other Information

Locus ID:

NCBI: 10288
MIM: 604815
HGNC: 6606
Ensembl: ENSG00000131042

Variants:

dbSNP: 10288
ClinVar: 10288
TCGA: ENSG00000131042
COSMIC: LILRB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131042ENST00000314446Q8N423
ENSG00000131042ENST00000314446A2IXV5
ENSG00000131042ENST00000391746Q8N423
ENSG00000131042ENST00000391748Q8N423
ENSG00000131042ENST00000391748A2IXV5
ENSG00000131042ENST00000391749Q8N423
ENSG00000131042ENST00000434421Q8N423
ENSG00000131042ENST00000455108H7C0C3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
383939692024ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.0
383939692024ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.0
374816702023LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.3
376224622023ILT4 reprograms glucose metabolism to promote tumor progression in triple-negative breast cancer.0
374816702023LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.3
376224622023ILT4 reprograms glucose metabolism to promote tumor progression in triple-negative breast cancer.0
355693052022Prognostic significance of the immune checkpoint HLA-G/ILT-4 in the survival of patients with gastric cancer.3
357172592022LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.9
357541992022Genetic diversity of the LILRB1 and LILRB2 coding regions in an admixed Brazilian population sample.5
357577692022Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis.3
359116742022Placental Malaria is Associated with Higher LILRB2 Expression in Monocyte Subsets and Lower Anti-Malarial IgG Antibodies During Infancy.3
355693052022Prognostic significance of the immune checkpoint HLA-G/ILT-4 in the survival of patients with gastric cancer.3
357172592022LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.9
357541992022Genetic diversity of the LILRB1 and LILRB2 coding regions in an admixed Brazilian population sample.5
357577692022Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis.3

Citation

Dessen P

LILRB2 (leukocyte immunoglobulin like receptor B2)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52791/lilrb2