LILRB4 (leukocyte immunoglobulin like receptor B4)

2007-07-01  

Identity

HGNC
LILRB4
LOCATION
19q13.42
LOCUSID
11006
ALIAS
CD85K,ILT-3,ILT3,LIR-5,LIR5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11006
MIM: 604821
HGNC: 6608
Ensembl: ENSG00000186818

Variants:

dbSNP: 11006
ClinVar: 11006
TCGA: ENSG00000186818
COSMIC: LILRB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186818ENST00000270452A0A0A0MQW7
ENSG00000186818ENST00000391733A0A0A0MS20
ENSG00000186818ENST00000391734A8MUE1
ENSG00000186818ENST00000391736Q8NHJ6
ENSG00000186818ENST00000430952A0A0A0MSZ8
ENSG00000186818ENST00000434286C9JST2
ENSG00000186818ENST00000494796A0A087X0F8

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
156709762005HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.62
195356442009Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.45
188020772008Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
175137942007Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients.24
223875532012Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells.22
198609082009The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.20
193807662009Ig-like transcript 3 regulates expression of proinflammatory cytokines and migration of activated T cells.18
214545812011Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.17
179231192007Central role of ILT3 in the T suppressor cell cascade.16

Citation

Dessen P

LILRB4 (leukocyte immunoglobulin like receptor B4)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47591/lilrb4