LIN54 (lin-54 DREAM MuvB core complex component)

2014-11-01  

Identity

HGNC
LIN54
LOCATION
4q21.22
LOCUSID
132660
ALIAS
CXCDC1,JC8.6,MIP120,TCX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 132660
MIM: 613367
HGNC: 25397
Ensembl: ENSG00000189308

Variants:

dbSNP: 132660
ClinVar: 132660
TCGA: ENSG00000189308
COSMIC: LIN54

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189308ENST00000340417Q6MZP7
ENSG00000189308ENST00000340417A0A024RDD8
ENSG00000189308ENST00000442461Q6MZP7
ENSG00000189308ENST00000446851Q6MZP7
ENSG00000189308ENST00000505397Q6MZP7
ENSG00000189308ENST00000505397A0A024RDD8
ENSG00000189308ENST00000506560Q6MZP7
ENSG00000189308ENST00000508171Q6MZP7
ENSG00000189308ENST00000510557Q6MZP7
ENSG00000189308ENST00000510877D6REW4

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Polo-like kinase mediated eventsREACTOMER-HSA-156711

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197258792009LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence-specific manner.36
274652582016Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters.15
228951752012LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression.7

Citation

Dessen P

LIN54 (lin-54 DREAM MuvB core complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65278/lin54