LIN7B (lin-7 homolog B, crumbs cell polarity complex component)

2014-11-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
LIN-7B,MALS-2,MALS2,VELI2

Other Information

Locus ID:

NCBI: 64130
MIM: 612331
HGNC: 17788
Ensembl: ENSG00000104863

Variants:

dbSNP: 64130
ClinVar: 64130
TCGA: ENSG00000104863
COSMIC: LIN7B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104863ENST00000221459Q9HAP6
ENSG00000104863ENST00000391864Q9HAP6
ENSG00000104863ENST00000486217S4R3R4
ENSG00000104863ENST00000595200M0R2U1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate Rhotekin and RhophilinsREACTOMER-HSA-5666185
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

References

Pubmed IDYearTitleCitations
153178152004PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.28
169797702006Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.13
145969092003MALS is a binding partner of IRSp53 at cell-cell contacts.12
182866322008Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.12
207205082010Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.6
251962152015Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders.5

Citation

Dessen P

LIN7B (lin-7 homolog B, crumbs cell polarity complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65280/lin7b