LIN9 (lin-9 DREAM MuvB core complex component)

2007-02-01  

Identity

HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
BARA,BARPsv,Lin-9,TGS,TGS1,TGS2
FUSION GENES

Other Information

Locus ID:

NCBI: 286826
MIM: 609375
HGNC: 30830
Ensembl: ENSG00000183814

Variants:

dbSNP: 286826
ClinVar: 286826
TCGA: ENSG00000183814
COSMIC: LIN9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183814ENST00000328205Q5TKA1
ENSG00000183814ENST00000359525B1B047
ENSG00000183814ENST00000366808H0Y322
ENSG00000183814ENST00000460719H7C4T7
ENSG00000183814ENST00000481685C9J5J4

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Polo-like kinase mediated eventsREACTOMER-HSA-156711

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
171598992007The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis.57
175637502007Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.56
233819442013A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.31
170987332007Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1.23
203608442010Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.21
241417692014A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c).18
280614492017Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.10
155383852004Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein.0
167303502006A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.0

Citation

Dessen P

LIN9 (lin-9 DREAM MuvB core complex component)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46365/lin9