LINGO1 (leucine rich repeat and Ig domain containing 1)

2007-02-01  

Identity

HGNC
LINGO1
LOCATION
15q24.3
LOCUSID
84894
ALIAS
LERN1,LRRN6A,MRT64,UNQ201
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84894
MIM: 609791
HGNC: 21205
Ensembl: ENSG00000169783

Variants:

dbSNP: 84894
ClinVar: 84894
TCGA: ENSG00000169783
COSMIC: LINGO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169783ENST00000355300Q96FE5
ENSG00000169783ENST00000557798H0YMX3
ENSG00000169783ENST00000559893H0YNK7
ENSG00000169783ENST00000561030Q96FE5
ENSG00000169783ENST00000561686H3BQ49
ENSG00000169783ENST00000562933H3BS32
ENSG00000169783ENST00000564472H3BM59
ENSG00000169783ENST00000566711H3BN48
ENSG00000169783ENST00000567726H3BMN3
ENSG00000169783ENST00000570216H3BMW2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth inhibition (RHOA activation)REACTOMER-HSA-193634

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191828062009Variant in the sequence of the LINGO1 gene confers risk of essential tremor.59
191828062009Variant in the sequence of the LINGO1 gene confers risk of essential tremor.59
177261132007Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.50
203693712010LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.39
203693712010LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.39
225142752012LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions.34
170055552006The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.31
172390122007TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.28
146868912003LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex.25
193630352009LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension.23

Citation

Dessen P

LINGO1 (leucine rich repeat and Ig domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46531/lingo1