LINGO2 (leucine rich repeat and Ig domain containing 2)

2019-08-01  

Identity

HGNC
LINGO2
LOCATION
9p21.2
LOCUSID
158038
ALIAS
LERN3,LRRN6C

Other Information

Locus ID:

NCBI: 158038
MIM: 609793
HGNC: 21207
Ensembl: ENSG00000174482

Variants:

dbSNP: 158038
ClinVar: 158038
TCGA: ENSG00000174482
COSMIC: LINGO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174482ENST00000308675Q7L985
ENSG00000174482ENST00000379992Q7L985
ENSG00000174482ENST00000613945Q7L985

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203693712010LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.39
203693712010LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.39
212872032011Lingo2 variants associated with essential tremor and Parkinson's disease.14
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.7
257113072015Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes.6
306960802019Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome.4
221233112012LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan.1
304264922019A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population.1

Citation

Dessen P

LINGO2 (leucine rich repeat and Ig domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58054/lingo2