LIPC (lipase C, hepatic type)

2012-05-01 Affiliation

Identity

HGNC

LIPC

LOCATION

15q21.3

LOCUSID

3990

ALIAS

HDLCQ12,HL,HTGL,LIPH

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3990
MIM: 151670
HGNC: 6619
Ensembl: ENSG00000166035

Variants:

dbSNP: 3990
ClinVar: 3990
TCGA: ENSG00000166035
COSMIC: LIPC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166035	ENST00000299022	P11150
ENSG00000166035	ENST00000356113	P11150
ENSG00000166035	ENST00000414170	E7EUJ1
ENSG00000166035	ENST00000433326	E7EUK6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerolipid metabolism	KEGG	ko00561
Glycerolipid metabolism	KEGG	hsa00561
Metabolic pathways	KEGG	hsa01100
Acylglycerol degradation	KEGG	hsa_M00098
Acylglycerol degradation	KEGG	M00098
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Lipid digestion, mobilization, and transport	REACTOME	R-HSA-73923
Digestion of dietary lipid	REACTOME	R-HSA-192456
Lipoprotein metabolism	REACTOME	R-HSA-174824
Chylomicron-mediated lipid transport	REACTOME	R-HSA-174800

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA449688	fluvastatin	Chemical	ClinicalAnnotation	associated	PD	16103896
PA451089	pravastatin	Chemical	ClinicalAnnotation	associated	PD	16103896, 16115483
PA451363	simvastatin	Chemical	ClinicalAnnotation	associated	PD	16103896

References

Pubmed ID	Year	Title	Citations
18193043	2008	Newly identified loci that influence lipid concentrations and risk of coronary artery disease.	690
18354102	2008	Polymorphisms associated with cholesterol and risk of cardiovascular events.	250
20385819	2010	Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.	246
20385826	2010	Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).	199
20385826	2010	Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).	199
19936222	2009	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	151
20400780	2010	Candidate gene association resource (CARe): design, methods, and proof of concept.	102
20682687	2010	Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.	88
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19148283	2009	Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.	56

Citation

Dessen P

LIPC (lipase C, hepatic type)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/43641/lipc