LIPG (lipase G, endothelial type)

2010-09-01  

Identity

HGNC
LOCATION
18q21.1
LOCUSID
ALIAS
EDL,EL,PRO719
FUSION GENES

Other Information

Locus ID:

NCBI: 9388
MIM: 603684
HGNC: 6623
Ensembl: ENSG00000101670

Variants:

dbSNP: 9388
ClinVar: 9388
TCGA: ENSG00000101670
COSMIC: LIPG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101670ENST00000261292Q9Y5X9
ENSG00000101670ENST00000261292A0A024R2B5
ENSG00000101670ENST00000427224B4DTR8
ENSG00000101670ENST00000577628J3QQQ0
ENSG00000101670ENST00000579750A0A075B751
ENSG00000101670ENST00000580036Q9Y5X9
ENSG00000101670ENST00000583083J3KTN7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
Acylglycerol degradationKEGGhsa_M00098
Acylglycerol degradationKEGGM00098
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Digestion of dietary lipidREACTOMER-HSA-192456

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
181930432008Newly identified loci that influence lipid concentrations and risk of coronary artery disease.690
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126011782003Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.61
192870922009Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.60
192870922009Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.60
191482832009Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.56
145171672003Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase.40
180396502008The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.35
203709132010Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.35
173560472007Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies.30

Citation

Dessen P

LIPG (lipase G, endothelial type)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51665/lipg