Identity
HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
HGL,Hugl-2,LGL2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3993
MIM: 618483
HGNC: 6629
Ensembl: ENSG00000073350
Variants:
dbSNP: 3993
ClinVar: 3993
TCGA: ENSG00000073350
COSMIC: LLGL2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Tight junction | KEGG | ko04530 |
| Tight junction | KEGG | hsa04530 |
| Hippo signaling pathway | KEGG | hsa04390 |
| Hippo signaling pathway | KEGG | ko04390 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38720397 | 2024 | Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer. | 0 |
| 38720397 | 2024 | Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer. | 0 |
| 36192404 | 2022 | Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer. | 5 |
| 36192404 | 2022 | Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer. | 5 |
| 32385218 | 2020 | A human cell polarity protein Lgl2 regulates influenza A virus nucleoprotein exportation from nucleus in MDCK cells. | 4 |
| 32385218 | 2020 | A human cell polarity protein Lgl2 regulates influenza A virus nucleoprotein exportation from nucleus in MDCK cells. | 4 |
| 30996345 | 2019 | LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. | 77 |
| 31088962 | 2019 | Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2. | 6 |
| 31088964 | 2019 | Solving the structure of Lgl2, a difficult blind test of unsupervised structure determination. | 4 |
| 30996345 | 2019 | LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. | 77 |
| 31088962 | 2019 | Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2. | 6 |
| 31088964 | 2019 | Solving the structure of Lgl2, a difficult blind test of unsupervised structure determination. | 4 |
| 24513855 | 2014 | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl. | 27 |
| 24513855 | 2014 | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl. | 27 |
| 22580609 | 2013 | The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis. | 19 |
Citation
Dessen P
LLGL2 (LLGL scribble cell polarity complex component 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/41163/llgl2
