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LMAN2 (lectin, mannose binding 2)

Identity

Alias_namesC5orf8
chromosome 5 open reading frame 8
lectin, mannose-binding 2
Alias_symbol (synonym)GP36B
VIP36
Other alias
HGNC (Hugo) LMAN2
LocusID (NCBI) 10960
Atlas_Id 53019
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 177331562 and ends at 177351884 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LMAN2 (5q35.3) / AP3S1 (5q22.3)LMAN2 (5q35.3) / F12 (5q35.3)LMAN2 (5q35.3) / KAT6B (10q22.2)
LMAN2 (5q35.3) / MXD3 (5q35.3)LMAN2 (5q35.3) / PDLIM7 (5q35.3)LMAN2 5q35.3 / F12 5q35.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;5)(q35;q35) LMAN2/NSD1
t(5;14)(q35;q32) LMAN2/PAPOLA

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Prostate tumors: an overview
t(5;5)(q23;q35) LMAN2/AP3S1
LMAN2/F12 (5q35)
LMAN2/MXD3 (5q35)

External links

Nomenclature
HGNC (Hugo)LMAN2   16986
Cards
Entrez_Gene (NCBI)LMAN2  10960  lectin, mannose binding 2
AliasesC5orf8; GP36B; VIP36
GeneCards (Weizmann)LMAN2
Ensembl hg19 (Hinxton)ENSG00000169223 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169223 [Gene_View]  ENSG00000169223 [Sequence]  chr5:177331562-177351884 [Contig_View]  LMAN2 [Vega]
ICGC DataPortalENSG00000169223
TCGA cBioPortalLMAN2
AceView (NCBI)LMAN2
Genatlas (Paris)LMAN2
WikiGenes10960
SOURCE (Princeton)LMAN2
Genetics Home Reference (NIH)LMAN2
Genomic and cartography
GoldenPath hg38 (UCSC)LMAN2  -     chr5:177331562-177351884 -  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LMAN2  -     5q35.3   [Description]    (hg19-Feb_2009)
GoldenPathLMAN2 - 5q35.3 [CytoView hg19]  LMAN2 - 5q35.3 [CytoView hg38]
ImmunoBaseENSG00000169223
Mapping of homologs : NCBILMAN2 [Mapview hg19]  LMAN2 [Mapview hg38]
OMIM609551   
Gene and transcription
Genbank (Entrez)AK222609 AK292099 AK301607 AK308027 BC017263
RefSeq transcript (Entrez)NM_006816
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LMAN2
Cluster EST : UnigeneHs.75864 [ NCBI ]
CGAP (NCI)Hs.75864
Alternative Splicing GalleryENSG00000169223
Gene ExpressionLMAN2 [ NCBI-GEO ]   LMAN2 [ EBI - ARRAY_EXPRESS ]   LMAN2 [ SEEK ]   LMAN2 [ MEM ]
Gene Expression Viewer (FireBrowse)LMAN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10960
GTEX Portal (Tissue expression)LMAN2
Human Protein AtlasENSG00000169223-LMAN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12907   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12907  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12907
Splice isoforms : SwissVarQ12907
PhosPhoSitePlusQ12907
Domaine pattern : Prosite (Expaxy)L_LECTIN_LIKE (PS51328)   
Domains : Interpro (EBI)ConA-like_dom_sf    Lectin_leg    VIP36_lectin   
Domain families : Pfam (Sanger)Lectin_leg-like (PF03388)   
Domain families : Pfam (NCBI)pfam03388   
Conserved Domain (NCBI)LMAN2
DMDM Disease mutations10960
Blocks (Seattle)LMAN2
SuperfamilyQ12907
Human Protein Atlas [tissue]ENSG00000169223-LMAN2 [tissue]
Peptide AtlasQ12907
HPRD17285
IPIIPI00009950   IPI00966202   IPI00966452   IPI00966738   IPI00967014   
Protein Interaction databases
DIP (DOE-UCLA)Q12907
IntAct (EBI)Q12907
FunCoupENSG00000169223
BioGRIDLMAN2
STRING (EMBL)LMAN2
ZODIACLMAN2
Ontologies - Pathways
QuickGOQ12907
Ontology : AmiGOGolgi membrane  protein binding  mannose binding  mannose binding  extracellular space  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  integral component of plasma membrane  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  endoplasmic reticulum organization  Golgi organization  cell surface  protein transport  COPII-coated ER to Golgi transport vesicle  carbohydrate binding  heat shock protein binding  endoplasmic reticulum-Golgi intermediate compartment membrane  metal ion binding  positive regulation of phagocytosis  extracellular exosome  
Ontology : EGO-EBIGolgi membrane  protein binding  mannose binding  mannose binding  extracellular space  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  integral component of plasma membrane  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  endoplasmic reticulum organization  Golgi organization  cell surface  protein transport  COPII-coated ER to Golgi transport vesicle  carbohydrate binding  heat shock protein binding  endoplasmic reticulum-Golgi intermediate compartment membrane  metal ion binding  positive regulation of phagocytosis  extracellular exosome  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkLMAN2
Atlas of Cancer Signalling NetworkLMAN2
Wikipedia pathwaysLMAN2
Orthology - Evolution
OrthoDB10960
GeneTree (enSembl)ENSG00000169223
Phylogenetic Trees/Animal Genes : TreeFamLMAN2
HOGENOMQ12907
Homologs : HomoloGeneLMAN2
Homology/Alignments : Family Browser (UCSC)LMAN2
Gene fusions - Rearrangements
Fusion : MitelmanLMAN2/AP3S1 [5q35.3/5q22.3]  
Fusion : MitelmanLMAN2/F12 [5q35.3/5q35.3]  [t(5;5)(q35;q35)]  
Fusion PortalLMAN2 5q35.3 F12 5q35.3 LUAD
Fusion : QuiverLMAN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLMAN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LMAN2
dbVarLMAN2
ClinVarLMAN2
1000_GenomesLMAN2 
Exome Variant ServerLMAN2
ExAC (Exome Aggregation Consortium)ENSG00000169223
GNOMAD BrowserENSG00000169223
Varsome BrowserLMAN2
Genetic variants : HAPMAP10960
Genomic Variants (DGV)LMAN2 [DGVbeta]
DECIPHERLMAN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLMAN2 
Mutations
ICGC Data PortalLMAN2 
TCGA Data PortalLMAN2 
Broad Tumor PortalLMAN2
OASIS PortalLMAN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLMAN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLMAN2
Mutations and Diseases : HGMDLMAN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LMAN2
DgiDB (Drug Gene Interaction Database)LMAN2
DoCM (Curated mutations)LMAN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LMAN2 (select a term)
intoGenLMAN2
Cancer3DLMAN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609551   
Orphanet
DisGeNETLMAN2
MedgenLMAN2
Genetic Testing Registry LMAN2
NextProtQ12907 [Medical]
TSGene10960
GENETestsLMAN2
Target ValidationLMAN2
Huge Navigator LMAN2 [HugePedia]
snp3D : Map Gene to Disease10960
BioCentury BCIQLMAN2
ClinGenLMAN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10960
Chemical/Pharm GKB GenePA25919
Clinical trialLMAN2
Miscellaneous
canSAR (ICR)LMAN2 (select the gene name)
DataMed IndexLMAN2
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLMAN2
EVEXLMAN2
GoPubMedLMAN2
iHOPLMAN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:51:07 CET 2019
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