LMO3 (LIM domain only 3)

2004-05-01  

Identity

HGNC
LMO3
LOCATION
12p12.3
LOCUSID
55885
ALIAS
RBTN3,RBTNL2,RHOM3,Rhom-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55885
MIM: 180386
HGNC: 6643
Ensembl: ENSG00000048540

Variants:

dbSNP: 55885
ClinVar: 55885
TCGA: ENSG00000048540
COSMIC: LMO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000048540ENST00000261169Q8TAP4
ENSG00000048540ENST00000320122Q8TAP4
ENSG00000048540ENST00000320122A0A024RAT1
ENSG00000048540ENST00000354662Q8TAP4
ENSG00000048540ENST00000354662A0A024RAT1
ENSG00000048540ENST00000396205F6TDU8
ENSG00000048540ENST00000424192C9JE61
ENSG00000048540ENST00000441439Q8TAP4
ENSG00000048540ENST00000441439A0A024RAT1
ENSG00000048540ENST00000447609Q8TAP4
ENSG00000048540ENST00000447609A0A024RAT1
ENSG00000048540ENST00000453727Q05D86
ENSG00000048540ENST00000534946Q8TAP4
ENSG00000048540ENST00000534946A0A024RAT1
ENSG00000048540ENST00000535535Q8TAP4
ENSG00000048540ENST00000535535A0A024RAT1
ENSG00000048540ENST00000536172Q05D86
ENSG00000048540ENST00000537304Q8TAP4
ENSG00000048540ENST00000537304A0A024RAT1
ENSG00000048540ENST00000537757F5H3S4
ENSG00000048540ENST00000538020F5H4K9
ENSG00000048540ENST00000538051F5H2N9
ENSG00000048540ENST00000539232Q05D86
ENSG00000048540ENST00000539534F5H3S4
ENSG00000048540ENST00000540445Q8TAP4
ENSG00000048540ENST00000540590F5H4T0
ENSG00000048540ENST00000540848Q8TAP4
ENSG00000048540ENST00000540848A0A024RAT1
ENSG00000048540ENST00000541295Q8TAP4
ENSG00000048540ENST00000541589Q05D86
ENSG00000048540ENST00000541764F5H655
ENSG00000048540ENST00000541846Q8TAP4
ENSG00000048540ENST00000541846A0A024RAT1
ENSG00000048540ENST00000544754F6TDU8
ENSG00000048540ENST00000545436F5GZR3
ENSG00000048540ENST00000546279F5GYZ6
ENSG00000048540ENST00000546281F5H3S4
ENSG00000048540ENST00000616247A0A087WYA2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
159302762005LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.43
220116692012Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.43
233223012013Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.27
215732142011Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.23
199955582010LMO3 interacts with p53 and inhibits its transcriptional activity.16
238234772013Human but not mouse adipogenesis is critically dependent on LMO3.16
258292512015MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells.15
302190642018LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling.7
286699282017GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells.4
294366062018LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling.3

Citation

Dessen P

LMO3 (LIM domain only 3)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/418/lmo3