LMO7 (LIM domain 7)

2011-11-01  

Identity

HGNC
LOCATION
13q22.2
LOCUSID
ALIAS
FBX20,FBXO20,LMO7b,LOMP
FUSION GENES

Other Information

Locus ID:

NCBI: 4008
MIM: 604362
HGNC: 6646
Ensembl: ENSG00000136153

Variants:

dbSNP: 4008
ClinVar: 4008
TCGA: ENSG00000136153
COSMIC: LMO7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136153ENST00000321797E9PMT2
ENSG00000136153ENST00000341547Q8WWI1
ENSG00000136153ENST00000357063J3KP06
ENSG00000136153ENST00000377499E9PMP7
ENSG00000136153ENST00000377534F8WD26
ENSG00000136153ENST00000447038H0Y424
ENSG00000136153ENST00000465261A0A0A0MTE2
ENSG00000136153ENST00000489941E9PK58
ENSG00000136153ENST00000497947E9PLU6
ENSG00000136153ENST00000524651H0YDG6
ENSG00000136153ENST00000525107H0YE95
ENSG00000136153ENST00000525373E9PJ10
ENSG00000136153ENST00000525914H0YDQ3
ENSG00000136153ENST00000526202E9PMS6
ENSG00000136153ENST00000526371E9PRJ0
ENSG00000136153ENST00000526528E9PRE3
ENSG00000136153ENST00000533809U3KQE6
ENSG00000136153ENST00000534657E9PMJ6

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Adherens junctionKEGGhsa04520
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170679982006Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes.56
215250342011Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes.24
216701542011LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.22
280261212017Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7.21
291581642018LMO7 exerts an effect on mitosis progression and the spindle assembly checkpoint.2
267860592016Knockdown of Lmo7 inhibits chick myogenesis.1
279888572017Association of LIM Domain 7 Gene Polymorphisms and Plasma Levels of LIM Domain 7 with Dilated Cardiomyopathy in a Chinese Population.1
297681052018Identification of a Recurrent LMO7-BRAF Fusion in Papillary Thyroid Carcinoma.1
304290172018LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease.1

Citation

Dessen P

LMO7 (LIM domain 7)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52473/lmo7