LMX1A (LIM homeobox transcription factor 1 alpha)

2011-03-01 Affiliation

Identity

HGNC

LMX1A

LOCATION

1q23.3

LOCUSID

4009

ALIAS

DFNA7,LMX1,LMX1.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4009
MIM: 600298
HGNC: 6653
Ensembl: ENSG00000162761

Variants:

dbSNP: 4009
ClinVar: 4009
TCGA: ENSG00000162761
COSMIC: LMX1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162761	ENST00000294816	Q8TE12
ENSG00000162761	ENST00000342310	Q8TE12
ENSG00000162761	ENST00000367893	Q8TE12

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19536175	2009	Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.	30
18832589	2009	The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model.	29
21624811	2011	Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells.	28
24407576	2014	High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma.	25
19064610	2009	Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.	16
21159062	2011	Hypermethylation-mediated reduction of LMX1A expression in gastric cancer.	15
26526610	2015	Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.	15
15183721	2004	Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse.	10
21435346	2011	Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement.	10

Citation

Dessen P

LMX1A (LIM homeobox transcription factor 1 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52143/lmx1a