LNX1 (ligand of numb-protein X 1)

2007-02-01  

Identity

HGNC
LNX1
LOCATION
4q12
LOCUSID
84708
ALIAS
LNX,MPDZ,PDZRN2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84708
MIM: 609732
HGNC: 6657
Ensembl: ENSG00000072201

Variants:

dbSNP: 84708
ClinVar: 84708
TCGA: ENSG00000072201
COSMIC: LNX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072201ENST00000263925Q8TBB1
ENSG00000072201ENST00000306888Q8TBB1
ENSG00000072201ENST00000507168D6RE08
ENSG00000072201ENST00000510143D6RAH9
ENSG00000072201ENST00000512247D6RB76
ENSG00000072201ENST00000513421A0A0B4J209

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191320872009A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
153675972004Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.40
95359081998The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.27
175049292007Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme.23
161229402005LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2.19
228894112012Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase.14
179362762007c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1.13
160023212005Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas.11
220457312011Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.11

Citation

Dessen P

LNX1 (ligand of numb-protein X 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46071/lnx1