LPA (lipoprotein(a))

2008-05-01  

Identity

HGNC
LPA
LOCATION
6q25.3
LOCUSID
4018
ALIAS
AK38,APOA,LP

Other Information

Locus ID:

NCBI: 4018
MIM: 152200
HGNC: 6667
Ensembl: ENSG00000198670

Variants:

dbSNP: 4018
ClinVar: 4018
TCGA: ENSG00000198670
COSMIC: LPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198670ENST00000316300P08519
ENSG00000198670ENST00000447678P08519
ENSG00000198670ENST00000614786A0A087WWY0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociatedPD22331829, 23903772, 25350695, 27045730, 29703846
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD22331829, 23903772, 25350695, 27045730, 29703846

References

Pubmed IDYearTitleCitations
200323232009Genetic variants associated with Lp(a) lipoprotein level and coronary disease.312
195093802009Genetically elevated lipoprotein(a) and increased risk of myocardial infarction.214
184649132008A genome-wide association study identifies protein quantitative trait loci (pQTLs).184
209713642010A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.181
233880022013Genetic associations with valvular calcification and aortic stenosis.162
191986112009Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.153
191986112009Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.153
270057782016Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.116
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
185941182008A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma.84

Citation

Dessen P

LPA (lipoprotein(a))

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50112/lpa