LPAR4 (lysophosphatidic acid receptor 4)

2011-02-01  

Identity

HGNC
LOCATION
Xq21.1
LOCUSID
ALIAS
GPR23,LPA4,P2RY9,P2Y5-LIKE,P2Y9

Other Information

Locus ID:

NCBI: 2846
MIM: 300086
HGNC: 4478
Ensembl: ENSG00000147145

Variants:

dbSNP: 2846
ClinVar: 2846
TCGA: ENSG00000147145
COSMIC: LPAR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147145ENST00000435339Q99677
ENSG00000147145ENST00000514744V9GY74
ENSG00000147145ENST00000614823Q99677

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127243202003Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.149
269413972016Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations.31
200695652010LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4.30
208907652010Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells.7
258498922015Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells.7
198606252009Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.5
292402502018Microrna-139-5p inhibits epithelial-mesenchymal transition and fibrosis in post-menopausal women with interstitial cystitis by targeting LPAR4 via the PI3K/Akt signaling pathway.5
296219542019LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts.1
234677512013Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells.0

Citation

Dessen P

LPAR4 (lysophosphatidic acid receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52043/lpar4