LPAR5 (lysophosphatidic acid receptor 5)

2014-08-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
GPR92,GPR93,KPG_010,LPA5
FUSION GENES

Other Information

Locus ID:

NCBI: 57121
MIM: 606926
HGNC: 13307
Ensembl: ENSG00000184574

Variants:

dbSNP: 57121
ClinVar: 57121
TCGA: ENSG00000184574
COSMIC: LPAR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184574ENST00000329858Q9H1C0
ENSG00000184574ENST00000329858Q5KU18
ENSG00000184574ENST00000431922Q9H1C0
ENSG00000184574ENST00000431922Q5KU18

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Lysosphingolipid and LPA receptorsREACTOMER-HSA-419408
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167749272006GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5.142
193667022009Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.53
184996772008Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.52
200695652010LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4.30
218322422011Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.22
214649382011LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release.19
252946702015Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma.9
258498922015Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells.7
198606252009Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.5
294096862018LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.5

Citation

Dessen P

LPAR5 (lysophosphatidic acid receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54426/lpar5