LPCAT2 (lysophosphatidylcholine acyltransferase 2)

2015-11-01  

Identity

HGNC
LOCATION
16q12.2
LOCUSID
ALIAS
AGPAT11,AYTL1,LysoPAFAT
FUSION GENES

Other Information

Locus ID:

NCBI: 54947
MIM: 612040
HGNC: 26032
Ensembl: ENSG00000087253

Variants:

dbSNP: 54947
ClinVar: 54947
TCGA: ENSG00000087253
COSMIC: LPCAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087253ENST00000262134Q7L5N7
ENSG00000087253ENST00000564084H3BU68

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PCREACTOMER-HSA-1482788

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
171826122007A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
214985052011Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.53
254119672014A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.24
203638362010Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
238441242013Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses.8
210480312011Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.5

Citation

Dessen P

LPCAT2 (lysophosphatidylcholine acyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/55528/lpcat2