LPXN (leupaxin)

2007-08-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
LDPL
FUSION GENES

Other Information

Locus ID:

NCBI: 9404
MIM: 605390
HGNC: 14061
Ensembl: ENSG00000110031

Variants:

dbSNP: 9404
ClinVar: 9404
TCGA: ENSG00000110031
COSMIC: LPXN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110031ENST00000395074O60711
ENSG00000110031ENST00000528489B7Z5P7
ENSG00000110031ENST00000528954O60711
ENSG00000110031ENST00000530561E9PNX9

Expression (GTEx)

0
50
100
150
200
250

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
173293982007Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.21
126743282003Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast.19
205435622010Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading.15
176408672007Leupaxin negatively regulates B cell receptor signaling.14
184973312008The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.12
184510962008Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
199170542010LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.9
268665732016Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.8

Citation

Dessen P

LPXN (leupaxin)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47705/lpxn