LRFN5 (leucine rich repeat and fibronectin type III domain containing 5)

2014-11-01  

Identity

HGNC
LRFN5
LOCATION
14q21.1
LOCUSID
145581
ALIAS
C14orf146,FIGLER8,SALM5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 145581
MIM: 612811
HGNC: 20360
Ensembl: ENSG00000165379

Variants:

dbSNP: 145581
ClinVar: 145581
TCGA: ENSG00000165379
COSMIC: LRFN5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165379ENST00000298119Q96NI6
ENSG00000165379ENST00000554120G3V4N1
ENSG00000165379ENST00000554171G3V364

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
204101092010Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.38
217369482011The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.19
293485792018Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation.15
293484292018Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation.12
311521572019Microdeletion of pseudogene chr14.232.a affects LRFN5 expression in cells of a patient with autism spectrum disorder.2

Citation

Dessen P

LRFN5 (leucine rich repeat and fibronectin type III domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68580/lrfn5