Identity
HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
A2MR,APOER,APR,CD91,IGFBP-3R,IGFBP3R,IGFBP3R1,KPA,LRP,LRP1A,TGFBR5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4035
MIM: 107770
HGNC: 6692
Ensembl: ENSG00000123384
Variants:
dbSNP: 4035
ClinVar: 4035
TCGA: ENSG00000123384
COSMIC: LRP1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA150595617 | platinum | Chemical | Literature | not associated | 24643204 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38278526 | 2024 | A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation. | 1 |
| 38279679 | 2024 | Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins. | 0 |
| 38488124 | 2024 | Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation. | 0 |
| 38278526 | 2024 | A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation. | 1 |
| 38279679 | 2024 | Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins. | 0 |
| 38488124 | 2024 | Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation. | 0 |
| 36608691 | 2023 | LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens. | 4 |
| 36842607 | 2023 | Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell. | 5 |
| 36880731 | 2023 | Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption. | 2 |
| 37036005 | 2023 | LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4. | 3 |
| 37060729 | 2023 | Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation. | 3 |
| 37072184 | 2023 | Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses. | 5 |
| 37107705 | 2023 | Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development. | 0 |
| 37305557 | 2023 | Exome-wide analysis reveals role of LRP1 and additional novel loci in cognition. | 1 |
| 37310025 | 2023 | Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer. | 1 |
Citation
Dessen P
LRP1 (LDL receptor related protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41199/lrp1
