LRPAP1 (LDL receptor related protein associated protein 1)

2008-12-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
A2MRAP,A2RAP,HBP44,MRAP,MYP23,RAP,alpha-2-MRAP
FUSION GENES

Other Information

Locus ID:

NCBI: 4043
MIM: 104225
HGNC: 6701
Ensembl: ENSG00000163956

Variants:

dbSNP: 4043
ClinVar: 4043
TCGA: ENSG00000163956
COSMIC: LRPAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163956ENST00000515119D6REW6
ENSG00000163956ENST00000648517A0A3B3IRQ7
ENSG00000163956ENST00000650182P30533

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
180555452007Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells.48
238305142013Mutations in LRPAP1 are associated with severe myopia in humans.31
204039972010Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.30
198260102009Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.23
126375032003Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain.18
210629712011Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.14
165175932006Interaction of lipoprotein lipase and receptor-associated protein.11
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

LRPAP1 (LDL receptor related protein associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50604/lrpap1