Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64101
MIM: 610486
HGNC: 15586
Ensembl: ENSG00000128594
Variants:
dbSNP: 64101
ClinVar: 64101
TCGA: ENSG00000128594
COSMIC: LRRC4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000128594 | ENST00000249363 | Q9HBW1 |
| ENSG00000128594 | ENST00000476782 | C9JA92 |
| ENSG00000128594 | ENST00000478726 | C9J7K7 |
| ENSG00000128594 | ENST00000494115 | C9J7V8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Axon guidance | KEGG | ko04360 |
| Cell adhesion molecules (CAMs) | KEGG | ko04514 |
| Axon guidance | KEGG | hsa04360 |
| Cell adhesion molecules (CAMs) | KEGG | hsa04514 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36780420 | 2023 | Leucine-rich repeats containing 4 protein (LRRC4) in memory, psychoneurosis, and glioblastoma. | 0 |
| 36780420 | 2023 | Leucine-rich repeats containing 4 protein (LRRC4) in memory, psychoneurosis, and glioblastoma. | 0 |
| 32372061 | 2020 | Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide. | 8 |
| 32372061 | 2020 | Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide. | 8 |
| 30790560 | 2019 | Identification of Coiled-Coil Domain-Containing Protein 180 and Leucine-Rich Repeat-Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue. | 3 |
| 30790560 | 2019 | Identification of Coiled-Coil Domain-Containing Protein 180 and Leucine-Rich Repeat-Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue. | 3 |
| 27612424 | 2016 | Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma. | 26 |
| 27884160 | 2016 | The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells. | 23 |
| 27612424 | 2016 | Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma. | 26 |
| 27884160 | 2016 | The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells. | 23 |
| 24404152 | 2014 | Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4. | 29 |
| 24563334 | 2014 | LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population. | 4 |
| 24404152 | 2014 | Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4. | 29 |
| 24563334 | 2014 | LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population. | 4 |
| 22834685 | 2012 | LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway. | 27 |
Citation
Dessen P
LRRC4 (leucine rich repeat containing 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/41203/lrrc4
