Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LRRC7 (leucine rich repeat containing 7)

Identity

Alias_symbol (synonym)KIAA1365
densin-180
Other aliasDENSIN
HGNC (Hugo) LRRC7
LocusID (NCBI) 57554
Atlas_Id 68646
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 69567185 and ends at 70123488 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAZ2B (2q24.2) / LRRC7 (1p31.1)FAF1 (1p32.3) / LRRC7 (1p31.1)FUBP1 (1p31.1) / LRRC7 (1p31.1)
KIAA1147 (7q34) / LRRC7 (1p31.1)LRRC7 (1p31.1) / MLLT1 (19p13.3)FAF1 LRRC7
FUBP1 LRRC7

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LRRC7   18531
Cards
Entrez_Gene (NCBI)LRRC7  57554  leucine rich repeat containing 7
AliasesDENSIN
GeneCards (Weizmann)LRRC7
Ensembl hg19 (Hinxton)ENSG00000033122 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000033122 [Gene_View]  ENSG00000033122 [Sequence]  chr1:69567185-70123488 [Contig_View]  LRRC7 [Vega]
ICGC DataPortalENSG00000033122
TCGA cBioPortalLRRC7
AceView (NCBI)LRRC7
Genatlas (Paris)LRRC7
WikiGenes57554
SOURCE (Princeton)LRRC7
Genetics Home Reference (NIH)LRRC7
Genomic and cartography
GoldenPath hg38 (UCSC)LRRC7  -     chr1:69567185-70123488 +  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRC7  -     1p31.1   [Description]    (hg19-Feb_2009)
GoldenPathLRRC7 - 1p31.1 [CytoView hg19]  LRRC7 - 1p31.1 [CytoView hg38]
ImmunoBaseENSG00000033122
Mapping of homologs : NCBILRRC7 [Mapview hg19]  LRRC7 [Mapview hg38]
OMIM614453   
Gene and transcription
Genbank (Entrez)AB037786 AF434715 AF498274 AK294206 BC080568
RefSeq transcript (Entrez)NM_001330635 NM_001350216 NM_001366836 NM_001366837 NM_001366838 NM_001366839 NM_001366840 NM_001366841 NM_001366842 NM_001370785 NM_020794
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRC7
Cluster EST : UnigeneHs.736929 [ NCBI ]
CGAP (NCI)Hs.736929
Alternative Splicing GalleryENSG00000033122
Gene ExpressionLRRC7 [ NCBI-GEO ]   LRRC7 [ EBI - ARRAY_EXPRESS ]   LRRC7 [ SEEK ]   LRRC7 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRC7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57554
GTEX Portal (Tissue expression)LRRC7
Human Protein AtlasENSG00000033122-LRRC7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NW7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NW7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NW7
Splice isoforms : SwissVarQ96NW7
PhosPhoSitePlusQ96NW7
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    PDZ (PS50106)   
Domains : Interpro (EBI)Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    PDZ    PDZ_sf   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam13855    pfam00595   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  PDZ (SM00228)  
Conserved Domain (NCBI)LRRC7
DMDM Disease mutations57554
Blocks (Seattle)LRRC7
SuperfamilyQ96NW7
Human Protein Atlas [tissue]ENSG00000033122-LRRC7 [tissue]
Peptide AtlasQ96NW7
HPRD09930
IPIIPI00426267   IPI01013180   IPI00943337   IPI00426269   IPI00384313   
Protein Interaction databases
DIP (DOE-UCLA)Q96NW7
IntAct (EBI)Q96NW7
FunCoupENSG00000033122
BioGRIDLRRC7
STRING (EMBL)LRRC7
ZODIACLRRC7
Ontologies - Pathways
QuickGOQ96NW7
Ontology : AmiGOMAPK cascade  protein binding  extracellular region  cytosol  cell-cell junction  cell-cell adherens junction  ionotropic glutamate receptor complex  positive regulation of neuron projection development  postsynaptic density  basolateral plasma membrane  cell junction  ionotropic glutamate receptor binding  specific granule lumen  neuron projection  receptor clustering  axon initial segment  neutrophil degranulation  establishment or maintenance of epithelial cell apical/basal polarity  synapse  postsynaptic membrane  receptor localization to synapse  cell-cell adhesion  neurotransmitter receptor transport, endosome to postsynaptic membrane  neurotransmitter receptor transport postsynaptic membrane to endosome  regulation of NMDA receptor activity  
Ontology : EGO-EBIMAPK cascade  protein binding  extracellular region  cytosol  cell-cell junction  cell-cell adherens junction  ionotropic glutamate receptor complex  positive regulation of neuron projection development  postsynaptic density  basolateral plasma membrane  cell junction  ionotropic glutamate receptor binding  specific granule lumen  neuron projection  receptor clustering  axon initial segment  neutrophil degranulation  establishment or maintenance of epithelial cell apical/basal polarity  synapse  postsynaptic membrane  receptor localization to synapse  cell-cell adhesion  neurotransmitter receptor transport, endosome to postsynaptic membrane  neurotransmitter receptor transport postsynaptic membrane to endosome  regulation of NMDA receptor activity  
NDEx NetworkLRRC7
Atlas of Cancer Signalling NetworkLRRC7
Wikipedia pathwaysLRRC7
Orthology - Evolution
OrthoDB57554
GeneTree (enSembl)ENSG00000033122
Phylogenetic Trees/Animal Genes : TreeFamLRRC7
HOGENOMQ96NW7
Homologs : HomoloGeneLRRC7
Homology/Alignments : Family Browser (UCSC)LRRC7
Gene fusions - Rearrangements
Fusion PortalFAF1 LRRC7
Fusion PortalFUBP1 LRRC7
Fusion : QuiverLRRC7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRC7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC7
dbVarLRRC7
ClinVarLRRC7
1000_GenomesLRRC7 
Exome Variant ServerLRRC7
ExAC (Exome Aggregation Consortium)ENSG00000033122
GNOMAD BrowserENSG00000033122
Varsome BrowserLRRC7
Genetic variants : HAPMAP57554
Genomic Variants (DGV)LRRC7 [DGVbeta]
DECIPHERLRRC7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRC7 
Mutations
ICGC Data PortalLRRC7 
TCGA Data PortalLRRC7 
Broad Tumor PortalLRRC7
OASIS PortalLRRC7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRC7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLRRC7
Mutations and Diseases : HGMDLRRC7
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LRRC7
DgiDB (Drug Gene Interaction Database)LRRC7
DoCM (Curated mutations)LRRC7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRC7 (select a term)
intoGenLRRC7
Cancer3DLRRC7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614453   
Orphanet
DisGeNETLRRC7
MedgenLRRC7
Genetic Testing Registry LRRC7
NextProtQ96NW7 [Medical]
TSGene57554
GENETestsLRRC7
Target ValidationLRRC7
Huge Navigator LRRC7 [HugePedia]
snp3D : Map Gene to Disease57554
BioCentury BCIQLRRC7
ClinGenLRRC7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57554
Chemical/Pharm GKB GenePA134879588
Clinical trialLRRC7
Miscellaneous
canSAR (ICR)LRRC7 (select the gene name)
DataMed IndexLRRC7
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRC7
EVEXLRRC7
GoPubMedLRRC7
iHOPLRRC7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 15:51:12 CEST 2019
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