LRWD1 (leucine rich repeats and WD repeat domain containing 1)

2017-04-01  

Identity

HGNC
LRWD1
LOCATION
7q22.1
LOCUSID
222229
ALIAS
CENP-33,ORCA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 222229
MIM: 615167
HGNC: 21769
Ensembl: ENSG00000161036

Variants:

dbSNP: 222229
ClinVar: 222229
TCGA: ENSG00000161036
COSMIC: LRWD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161036ENST00000292616Q9UFC0
ENSG00000161036ENST00000292616A0A140VJD0
ENSG00000161036ENST00000463739F8WDB4
ENSG00000161036ENST00000464107F8WBP5
ENSG00000161036ENST00000468175H7C5N7
ENSG00000161036ENST00000476270H7C4Q9
ENSG00000161036ENST00000485808H7C5S6
ENSG00000161036ENST00000626402F8WBP5

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
209324782010A WD-repeat protein stabilizes ORC binding to chromatin.53
226453142012Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.25
259229092015The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin.21
224276552012Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.15
229357132012Orc2 protects ORCA from ubiquitin-mediated degradation.11
277603812017High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability.4
232750292012Nuclear factor-κB (NF-κB) regulates the expression of human testis-enriched Leucine-rich repeats and WD repeat domain containing 1 (LRWD1) gene.3
285694022018LRWD1 Regulates Microtubule Nucleation and Proper Cell Cycle Progression in the Human Testicular Embryonic Carcinoma Cells.2
234453712014Single-nucleotide polymorphisms in the LRWD1 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome.1
251708212014Correlation between leucine rich domain and the stability of LRWD1 protein in human NT2/D1 cells.0

Citation

Dessen P

LRWD1 (leucine rich repeats and WD repeat domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56845/lrwd1