LSM1 (LSM1 homolog, mRNA degradation associated)

2003-02-01  

Identity

HGNC
LOCATION
8p11.23
LOCUSID
ALIAS
CASM,YJL124C
FUSION GENES

Other Information

Locus ID:

NCBI: 27257
MIM: 607281
HGNC: 20472
Ensembl: ENSG00000175324

Variants:

dbSNP: 27257
ClinVar: 27257
TCGA: ENSG00000175324
COSMIC: LSM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175324ENST00000311351O15116
ENSG00000175324ENST00000311351A0A0S2Z590
ENSG00000175324ENST00000520755E5RH18
ENSG00000175324ENST00000523511E5RJ47

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Lsm 1-7 complexKEGGhsa_M00397
Lsm 1-7 complexKEGGM00397
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

References

Pubmed IDYearTitleCitations
125153822002The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.181
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170013082007Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon.23
182189952008CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes.9
258724762015LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.6
119538272002Down-regulation of Lsm1 is involved in human prostate cancer progression.4
240355622013Further evidence for the association between the LSM1 gene and schizophrenia.1

Citation

Dessen P

LSM1 (LSM1 homolog, mRNA degradation associated)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41208/lsm1