LSM14A (LSM14A mRNA processing body assembly factor)

2014-08-01  

Identity

HGNC
LSM14A
LOCATION
19q13.11
LOCUSID
26065
ALIAS
C19orf13,FAM61A,RAP55,RAP55A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26065
MIM: 610677
HGNC: 24489
Ensembl: ENSG00000257103

Variants:

dbSNP: 26065
ClinVar: 26065
TCGA: ENSG00000257103
COSMIC: LSM14A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000257103ENST00000433627Q8ND56
ENSG00000257103ENST00000540746Q8ND56
ENSG00000257103ENST00000544216Q8ND56
ENSG00000257103ENST00000585887A0A096LP11
ENSG00000257103ENST00000586157K7EMZ9
ENSG00000257103ENST00000589878I3L4Q1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
227451632012LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.56
229730322012The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection.30
187231152009RAP55: insights into an evolutionarily conserved protein family.18
226148392012PRMT1 is required for RAP55 to localize to processing bodies.17
286667102017Homozygous alpha-synuclein p.A53V in familial Parkinson's disease.9
263398002015Localization and role of RAP55/LSM14 in HeLa cells: a new finding on the mitotic spindle assembly.3
269400282016Excessive Iron and α-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease.3

Citation

Dessen P

LSM14A (LSM14A mRNA processing body assembly factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54435/lsm14a