LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)

2007-02-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
GRP,YER112W
FUSION GENES

Other Information

Locus ID:

NCBI: 25804
MIM: 607284
HGNC: 17259
Ensembl: ENSG00000130520

Variants:

dbSNP: 25804
ClinVar: 25804
TCGA: ENSG00000130520
COSMIC: LSM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130520ENST00000252816U3KQK1
ENSG00000130520ENST00000593829Q9Y4Z0
ENSG00000130520ENST00000594828V9GZ56
ENSG00000130520ENST00000600289M0QXB0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U4/U6.U5 tri-snRNPKEGGhsa_M00354
Lsm 2-8 complexKEGGhsa_M00396
Lsm 1-7 complexKEGGhsa_M00397
Spliceosome, U4/U6.U5 tri-snRNPKEGGM00354
Lsm 2-8 complexKEGGM00396
Lsm 1-7 complexKEGGM00397
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384627402024METTL3-mediated the m6A modification of SF3B4 facilitates the development of non-small cell lung cancer by enhancing LSM4 expression.1
384627402024METTL3-mediated the m6A modification of SF3B4 facilitates the development of non-small cell lung cancer by enhancing LSM4 expression.1
369767472023[Phase Separation of Purified Human LSM4 Protein].0
369767472023[Phase Separation of Purified Human LSM4 Protein].0
332854222021Circ_0025033 promotes the progression of ovarian cancer by activating the expression of LSM4 via targeting miR-184.33
332854222021Circ_0025033 promotes the progression of ovarian cancer by activating the expression of LSM4 via targeting miR-184.33
272472662016The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.31
272472662016The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.31
242551652014The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation.20
242551652014The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation.20
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94
190884402008LSm4 associates with the plasma membrane and acts as a co-factor in cell volume regulation.10
190884402008LSm4 associates with the plasma membrane and acts as a co-factor in cell volume regulation.10
171788572006Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.68

Citation

Dessen P

LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46135/lsm4