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LSP1 (lymphocyte specific protein 1)

Identity

Alias_symbol (synonym)WP34
Other aliaspp52
HGNC (Hugo) LSP1
LocusID (NCBI) 4046
Atlas_Id 289
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1853084 and ends at 1892263 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCC1 (16p13.11) / LSP1 (11p15.5)DHFR (5q14.1) / LSP1 (11p15.5)GCDH (19p13.2) / LSP1 (11p15.5)
KRT12 (17q21.2) / LSP1 (11p15.5)LSP1 (11p15.5) / TNNT3 (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia Variant (HCL-V)

External links

Nomenclature
HGNC (Hugo)LSP1   6707
Cards
Entrez_Gene (NCBI)LSP1  4046  lymphocyte specific protein 1
AliasesWP34; pp52
GeneCards (Weizmann)LSP1
Ensembl hg19 (Hinxton)ENSG00000130592 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130592 [Gene_View]  ENSG00000130592 [Sequence]  chr11:1853084-1892263 [Contig_View]  LSP1 [Vega]
ICGC DataPortalENSG00000130592
TCGA cBioPortalLSP1
AceView (NCBI)LSP1
Genatlas (Paris)LSP1
WikiGenes4046
SOURCE (Princeton)LSP1
Genetics Home Reference (NIH)LSP1
Genomic and cartography
GoldenPath hg38 (UCSC)LSP1  -     chr11:1853084-1892263 +  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LSP1  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathLSP1 - 11p15.5 [CytoView hg19]  LSP1 - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000130592
genome Data Viewer NCBILSP1 [Mapview hg19]  
OMIM153432   
Gene and transcription
Genbank (Entrez)AI817126 AK056576 AK092071 AK093859 AK129684
RefSeq transcript (Entrez)NM_001013253 NM_001013254 NM_001013255 NM_001242932 NM_001289005 NM_002339
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LSP1
Alternative Splicing GalleryENSG00000130592
Gene ExpressionLSP1 [ NCBI-GEO ]   LSP1 [ EBI - ARRAY_EXPRESS ]   LSP1 [ SEEK ]   LSP1 [ MEM ]
Gene Expression Viewer (FireBrowse)LSP1 [ Firebrowse - Broad ]
GenevisibleExpression of LSP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4046
GTEX Portal (Tissue expression)LSP1
Human Protein AtlasENSG00000130592-LSP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33241
Splice isoforms : SwissVarP33241
PhosPhoSitePlusP33241
Domains : Interpro (EBI)Caldesmon_LSP    Lymphspecific   
Domain families : Pfam (Sanger)Caldesmon (PF02029)   
Domain families : Pfam (NCBI)pfam02029   
Conserved Domain (NCBI)LSP1
DMDM Disease mutations4046
Blocks (Seattle)LSP1
PDB (RSDB)3BH8    4NO0    4NO2   
PDB Europe3BH8    4NO0    4NO2   
PDB (PDBSum)3BH8    4NO0    4NO2   
PDB (IMB)3BH8    4NO0    4NO2   
Structural Biology KnowledgeBase3BH8    4NO0    4NO2   
SCOP (Structural Classification of Proteins)3BH8    4NO0    4NO2   
CATH (Classification of proteins structures)3BH8    4NO0    4NO2   
SuperfamilyP33241
Human Protein Atlas [tissue]ENSG00000130592-LSP1 [tissue]
Peptide AtlasP33241
HPRD01083
IPIIPI00013260   IPI00442986   IPI00903006   IPI00554652   IPI00789393   IPI00658134   IPI00657664   IPI00790783   IPI00853486   IPI00853303   IPI00853352   IPI00878040   
Protein Interaction databases
DIP (DOE-UCLA)P33241
IntAct (EBI)P33241
FunCoupENSG00000130592
BioGRIDLSP1
STRING (EMBL)LSP1
ZODIACLSP1
Ontologies - Pathways
QuickGOP33241
Ontology : AmiGOactin binding  plasma membrane  cellular defense response  signal transduction  actin cytoskeleton  membrane  extracellular exosome  
Ontology : EGO-EBIactin binding  plasma membrane  cellular defense response  signal transduction  actin cytoskeleton  membrane  extracellular exosome  
Pathways : KEGGTuberculosis   
NDEx NetworkLSP1
Atlas of Cancer Signalling NetworkLSP1
Wikipedia pathwaysLSP1
Orthology - Evolution
OrthoDB4046
GeneTree (enSembl)ENSG00000130592
Phylogenetic Trees/Animal Genes : TreeFamLSP1
HOGENOMP33241
Homologs : HomoloGeneLSP1
Homology/Alignments : Family Browser (UCSC)LSP1
Gene fusions - Rearrangements
Fusion : QuiverLSP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLSP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LSP1
dbVarLSP1
ClinVarLSP1
1000_GenomesLSP1 
Exome Variant ServerLSP1
GNOMAD BrowserENSG00000130592
Varsome BrowserLSP1
Genetic variants : HAPMAP4046
Genomic Variants (DGV)LSP1 [DGVbeta]
DECIPHERLSP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLSP1 
Mutations
ICGC Data PortalLSP1 
TCGA Data PortalLSP1 
Broad Tumor PortalLSP1
OASIS PortalLSP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLSP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLSP1
Mutations and Diseases : HGMDLSP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LSP1
DgiDB (Drug Gene Interaction Database)LSP1
DoCM (Curated mutations)LSP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LSP1 (select a term)
intoGenLSP1
Cancer3DLSP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153432   
Orphanet
DisGeNETLSP1
MedgenLSP1
Genetic Testing Registry LSP1
NextProtP33241 [Medical]
TSGene4046
GENETestsLSP1
Target ValidationLSP1
Huge Navigator LSP1 [HugePedia]
snp3D : Map Gene to Disease4046
BioCentury BCIQLSP1
ClinGenLSP1
Clinical trials, drugs, therapy
Protein Interactions : CTD4046
Pharm GKB GenePA30472
Clinical trialLSP1
Miscellaneous
canSAR (ICR)LSP1 (select the gene name)
HarmonizomeLSP1
DataMed IndexLSP1
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLSP1
EVEXLSP1
GoPubMedLSP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jul 10 19:26:20 CEST 2020
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