LTF (lactotransferrin)

2004-04-01  

Identity

HGNC
LTF
LOCATION
3p21.31
LOCUSID
4057
ALIAS
GIG12,HEL110,HLF2,LF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4057
MIM: 150210
HGNC: 6720
Ensembl: ENSG00000012223

Variants:

dbSNP: 4057
ClinVar: 4057
TCGA: ENSG00000012223
COSMIC: LTF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000012223ENST00000231751P02788
ENSG00000012223ENST00000231751V9HWI4
ENSG00000012223ENST00000417439E7ER44
ENSG00000012223ENST00000426532P02788
ENSG00000012223ENST00000431944C9JCF5
ENSG00000012223ENST00000443496E7EQB2

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Latent infection of Homo sapiens with Mycobacterium tuberculosisREACTOMER-HSA-1222352
Response of Mtb to phagocytosisREACTOMER-HSA-1222499
Mtb iron assimilation by chelationREACTOMER-HSA-1222449
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157
Metal sequestration by antimicrobial proteinsREACTOMER-HSA-6799990
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
lactating breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
120375682002A component of innate immunity prevents bacterial biofilm development.257
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
162612532005Lactoferrin: an important host defence against microbial and viral attack.83
162612562005Multifunctional roles of lactoferrin: a critical overview.79
174758662007Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion.76
190336482009Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185733122009Antimicrobial properties of lactoferrin.60
184536072008Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses.45
222617232012Glycosylation of human milk lactoferrin exhibits dynamic changes during early lactation enhancing its role in pathogenic bacteria-host interactions.43

Citation

Dessen P

LTF (lactotransferrin)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41217/ltf