LTK (leukocyte receptor tyrosine kinase)

2003-02-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
TYK1
FUSION GENES

Other Information

Locus ID:

NCBI: 4058
MIM: 151520
HGNC: 6721
Ensembl: ENSG00000062524

Variants:

dbSNP: 4058
ClinVar: 4058
TCGA: ENSG00000062524
COSMIC: LTK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000062524ENST00000263800P29376
ENSG00000062524ENST00000355166P29376
ENSG00000062524ENST00000453182P29376
ENSG00000062524ENST00000561619H3BVG6

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
266300102015Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.39
253318932014Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.18
146953572004Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.12
223475062012ALK-activating homologous mutations in LTK induce cellular transformation.9
312275932019LTK is an ER-resident receptor tyrosine kinase that regulates secretion.3

Citation

Dessen P

LTK (leukocyte receptor tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41218/ltk