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LUC7L2 (LUC7 like 2, pre-mRNA splicing factor)

Identity

Alias_namesLUC7-like 2 (S. cerevisiae)
Alias_symbol (synonym)CGI-74
CGI-59
H_NH0792N18.3
FLJ10657
LUC7B2
hLuc7B2
Other alias
HGNC (Hugo) LUC7L2
LocusID (NCBI) 51631
Atlas_Id 54830
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 139359846 and ends at 139423457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C7orf55 (7q34) / LUC7L2 (7q34)LOC100507412 (-) / LUC7L2 (7q34)LUC7L2 (7q34) / CHD2 (15q26.1)
LUC7L2 (7q34) / JAKMIP1 (4p16.1)LUC7L2 (7q34) / LUC7L2 (7q34)LUC7L2 (7q34) / NBAS (2p24.3)
LUC7L2 (7q34) / UBN2 (7q34)PTCH1 (9q22.32) / LUC7L2 (7q34)RAPGEF5 (7p15.3) / LUC7L2 (7q34)
TBX4 (17q23.2) / LUC7L2 (7q34)TTC12 (11q23.2) / LUC7L2 (7q34)ZBTB20 (3q13.31) / LUC7L2 (7q34)
LUC7L2 7q34 / JAKMIP1 4p16.1TTC12 11q23.2 / LUC7L2 7q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]

Solid Tumors TT_t0407p16q34ID106447 TT_t0711q34q23ID107391

External links

Nomenclature
HGNC (Hugo)LUC7L2   21608
Cards
Entrez_Gene (NCBI)LUC7L2  51631  LUC7 like 2, pre-mRNA splicing factor
AliasesCGI-59; CGI-74; LUC7B2
GeneCards (Weizmann)LUC7L2
Ensembl hg19 (Hinxton)ENSG00000146963 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146963 [Gene_View]  ENSG00000146963 [Sequence]  chr7:139359846-139423457 [Contig_View]  LUC7L2 [Vega]
ICGC DataPortalENSG00000146963
TCGA cBioPortalLUC7L2
AceView (NCBI)LUC7L2
Genatlas (Paris)LUC7L2
WikiGenes51631
SOURCE (Princeton)LUC7L2
Genetics Home Reference (NIH)LUC7L2
Genomic and cartography
GoldenPath hg38 (UCSC)LUC7L2  -     chr7:139359846-139423457 +  7q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LUC7L2  -     7q34   [Description]    (hg19-Feb_2009)
GoldenPathLUC7L2 - 7q34 [CytoView hg19]  LUC7L2 - 7q34 [CytoView hg38]
ImmunoBaseENSG00000146963
Mapping of homologs : NCBILUC7L2 [Mapview hg19]  LUC7L2 [Mapview hg38]
OMIM613056   
Gene and transcription
Genbank (Entrez)AF151817 AF151832 AK001476 AK001519 AK022895
RefSeq transcript (Entrez)NM_001244585 NM_001270643 NM_016019
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LUC7L2
Cluster EST : UnigeneHs.731488 [ NCBI ]
CGAP (NCI)Hs.731488
Alternative Splicing GalleryENSG00000146963
Gene ExpressionLUC7L2 [ NCBI-GEO ]   LUC7L2 [ EBI - ARRAY_EXPRESS ]   LUC7L2 [ SEEK ]   LUC7L2 [ MEM ]
Gene Expression Viewer (FireBrowse)LUC7L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51631
GTEX Portal (Tissue expression)LUC7L2
Human Protein AtlasENSG00000146963-LUC7L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y383   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y383  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y383
Splice isoforms : SwissVarQ9Y383
PhosPhoSitePlusQ9Y383
Domains : Interpro (EBI)Luc7-rel   
Domain families : Pfam (Sanger)LUC7 (PF03194)   
Domain families : Pfam (NCBI)pfam03194   
Conserved Domain (NCBI)LUC7L2
DMDM Disease mutations51631
Blocks (Seattle)LUC7L2
SuperfamilyQ9Y383
Human Protein Atlas [tissue]ENSG00000146963-LUC7L2 [tissue]
Peptide AtlasQ9Y383
HPRD17456
IPIIPI01012991   IPI01008748   IPI00006932   IPI00893216   IPI00893315   IPI00893087   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y383
IntAct (EBI)Q9Y383
FunCoupENSG00000146963
BioGRIDLUC7L2
STRING (EMBL)LUC7L2
ZODIACLUC7L2
Ontologies - Pathways
QuickGOQ9Y383
Ontology : AmiGORNA binding  mRNA binding  protein binding  U1 snRNP  mRNA splice site selection  nuclear speck  enzyme binding  U2-type prespliceosome  
Ontology : EGO-EBIRNA binding  mRNA binding  protein binding  U1 snRNP  mRNA splice site selection  nuclear speck  enzyme binding  U2-type prespliceosome  
NDEx NetworkLUC7L2
Atlas of Cancer Signalling NetworkLUC7L2
Wikipedia pathwaysLUC7L2
Orthology - Evolution
OrthoDB51631
GeneTree (enSembl)ENSG00000146963
Phylogenetic Trees/Animal Genes : TreeFamLUC7L2
HOGENOMQ9Y383
Homologs : HomoloGeneLUC7L2
Homology/Alignments : Family Browser (UCSC)LUC7L2
Gene fusions - Rearrangements
Fusion : MitelmanLUC7L2/JAKMIP1 [7q34/4p16.1]  
Fusion : MitelmanTTC12/LUC7L2 [11q23.2/7q34]  [t(7;11)(q34;q23)]  
Fusion PortalLUC7L2 7q34 JAKMIP1 4p16.1 BRCA
Fusion PortalTTC12 11q23.2 LUC7L2 7q34 HNSC
Fusion : QuiverLUC7L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLUC7L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LUC7L2
dbVarLUC7L2
ClinVarLUC7L2
1000_GenomesLUC7L2 
Exome Variant ServerLUC7L2
ExAC (Exome Aggregation Consortium)ENSG00000146963
GNOMAD BrowserENSG00000146963
Varsome BrowserLUC7L2
Genetic variants : HAPMAP51631
Genomic Variants (DGV)LUC7L2 [DGVbeta]
DECIPHERLUC7L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLUC7L2 
Mutations
ICGC Data PortalLUC7L2 
TCGA Data PortalLUC7L2 
Broad Tumor PortalLUC7L2
OASIS PortalLUC7L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLUC7L2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLUC7L2
Mutations and Diseases : HGMDLUC7L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LUC7L2
DgiDB (Drug Gene Interaction Database)LUC7L2
DoCM (Curated mutations)LUC7L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LUC7L2 (select a term)
intoGenLUC7L2
Cancer3DLUC7L2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613056   
Orphanet
DisGeNETLUC7L2
MedgenLUC7L2
Genetic Testing Registry LUC7L2
NextProtQ9Y383 [Medical]
TSGene51631
GENETestsLUC7L2
Target ValidationLUC7L2
Huge Navigator LUC7L2 [HugePedia]
snp3D : Map Gene to Disease51631
BioCentury BCIQLUC7L2
ClinGenLUC7L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51631
Chemical/Pharm GKB GenePA134873425
Clinical trialLUC7L2
Miscellaneous
canSAR (ICR)LUC7L2 (select the gene name)
DataMed IndexLUC7L2
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLUC7L2
EVEXLUC7L2
GoPubMedLUC7L2
iHOPLUC7L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:15:46 CEST 2019
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