LY6K (lymphocyte antigen 6 family member K)

2008-01-01  

Identity

HGNC
LY6K
LOCATION
8q24.3
LOCUSID
54742
ALIAS
CT97,HSJ001348,URLC10,ly-6K

Other Information

Locus ID:

NCBI: 54742
MIM: 615093
HGNC: 24225
Ensembl: ENSG00000160886

Variants:

dbSNP: 54742
ClinVar: 54742
TCGA: ENSG00000160886
COSMIC: LY6K

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160886ENST00000292430Q17RY6
ENSG00000160886ENST00000518841E5RGJ8
ENSG00000160886ENST00000519387Q17RY6
ENSG00000160886ENST00000522591H0YB07

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
177848732007Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy.45
180897892007Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas.44
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
271971812016Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance.19
220723282012Genome-wide expression and copy number analysis identifies driver genes in gingivobuccal cancers.13
229882412012The regulatory mechanism of the LY6K gene expression in human breast cancer cells.10
273040602016miRNAs involved in LY6K and estrogen receptor α contribute to tamoxifen-susceptibility in breast cancer.5
274948792016Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma.4
302491072018MiRNA-500a-3p inhibits cell proliferation and invasion by targeting lymphocyte antigen 6 complex locus K (LY6K) in human non-small cell lung cancer.3

Citation

Dessen P

LY6K (lymphocyte antigen 6 family member K)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49996/ly6k