LY75 (lymphocyte antigen 75)

2007-02-01  

Identity

HGNC
LOCATION
2q24.2
LOCUSID
ALIAS
CD205,CLEC13B,DEC-205,GP200-MR6,LY-75

Other Information

Locus ID:

NCBI: 4065
MIM: 604524
HGNC: 6729
Ensembl: ENSG00000054219

Variants:

dbSNP: 4065
ClinVar: 4065
TCGA: ENSG00000054219
COSMIC: LY75

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054219ENST00000263636O60449

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172298382007DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes.89
229881142012DEC-205 is a cell surface receptor for CpG oligonucleotides.59
185198102008Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses.52
192037522009oxLDL uptake by dendritic cells induces upregulation of scavenger-receptors, maturation and differentiation.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
227367942012Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo.27
214130032011DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells.24
197068882009Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity.20
255579502015Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.18
228657002012Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus.16

Citation

Dessen P

LY75 (lymphocyte antigen 75)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45578/ly75