LY86 (lymphocyte antigen 86)

2016-10-01  

Identity

HGNC
LOCATION
6p25.1
LOCUSID
ALIAS
MD-1,MD1,MMD-1,dJ80N2.1

Other Information

Locus ID:

NCBI: 9450
MIM: 605241
HGNC: 16837
Ensembl: ENSG00000112799

Variants:

dbSNP: 9450
ClinVar: 9450
TCGA: ENSG00000112799
COSMIC: LY86

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112799ENST00000230568O95711
ENSG00000112799ENST00000379953O95711

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209356292010Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.396
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
219592642011Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.16
247357452014DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation.9
180012952007Single nucleotide polymorphisms and haplotype of MD-1 gene associated with high serum IgE phenotype with mite-sensitive allergy in Taiwanese children.3
192556862008Association of single nucleotide polymorphisms of MD-1 gene with pediatric and adult asthma in the Taiwanese population.2
192556862008Association of single nucleotide polymorphisms of MD-1 gene with pediatric and adult asthma in the Taiwanese population.2
272090862016MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells.2
169077042006Lack of association between genetic variation in 9 innate immunity genes and baseline CRP levels.1
214267272011[Association of single nucleotide polymorphisms of MD-1 gene with asthma in adults of Han Nationality in Southern China].1

Citation

Dessen P

LY86 (lymphocyte antigen 86)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56351/ly86