LYAR (Ly1 antibody reactive)

2015-11-01  

Identity

HGNC
LYAR
LOCATION
4p16.3
LOCUSID
55646
ALIAS
ZC2HC2,ZLYAR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55646
MIM: 617684
HGNC: 26021
Ensembl: ENSG00000145220

Variants:

dbSNP: 55646
ClinVar: 55646
TCGA: ENSG00000145220
COSMIC: LYAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145220ENST00000343470Q9NX58
ENSG00000145220ENST00000452476Q9NX58
ENSG00000145220ENST00000513174D6RDJ1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
244952272014Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA.13
250929182014Human fetal globin gene expression is regulated by LYAR.12
264137502015LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression.8
249902472014Lyar, a cell growth-regulating zinc finger protein, was identified to be associated with cytoplasmic ribosomes in male germ and cancer cells.7
286865802017Upregulation of LYAR induces neuroblastoma cell proliferation and survival.3
314131312019LYAR Suppresses Beta Interferon Induction by Targeting Phosphorylated Interferon Regulatory Factor 3.1
315047942019LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.1

Citation

Dessen P

LYAR (Ly1 antibody reactive)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/55513/lyar