Identity
HGNC
LOCATION
8q12.1
LOCUSID
ALIAS
JTK8,p53Lyn,p56Lyn
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4067
MIM: 165120
HGNC: 6735
Ensembl: ENSG00000254087
Variants:
dbSNP: 4067
ClinVar: 4067
TCGA: ENSG00000254087
COSMIC: LYN
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000254087 | ENST00000519728 | P07948 |
| ENSG00000254087 | ENST00000520050 | E5RJ37 |
| ENSG00000254087 | ENST00000520220 | P07948 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38810320 | 2024 | A novel lncRNA associated with the prognosis of patients with colorectal cancer resists apoptosis through the LYN/BCL-2 pathway. | 0 |
| 38810320 | 2024 | A novel lncRNA associated with the prognosis of patients with colorectal cancer resists apoptosis through the LYN/BCL-2 pathway. | 0 |
| 36724904 | 2023 | Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug Resistance (MDR1) gene. | 1 |
| 36899005 | 2023 | LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1. | 4 |
| 36932076 | 2023 | Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome. | 6 |
| 37014138 | 2023 | Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer. | 3 |
| 36724904 | 2023 | Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug Resistance (MDR1) gene. | 1 |
| 36899005 | 2023 | LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1. | 4 |
| 36932076 | 2023 | Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome. | 6 |
| 37014138 | 2023 | Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer. | 3 |
| 36058999 | 2022 | Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer. | 4 |
| 36058999 | 2022 | Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer. | 4 |
| 33199837 | 2021 | Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model. | 2 |
| 33512474 | 2021 | CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1. | 13 |
| 33199837 | 2021 | Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model. | 2 |
Citation
Dessen P
LYN (LYN proto-oncogene, Src family tyrosine kinase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41221/lyn
