LYPLA1 (lysophospholipase 1)

2013-06-01  

Identity

HGNC
LOCATION
8q11.23
LOCUSID
ALIAS
APT-1,APT1,LPL-I,LPL1,hAPT1
FUSION GENES

Other Information

Locus ID:

NCBI: 10434
MIM: 605599
HGNC: 6737
Ensembl: ENSG00000120992

Variants:

dbSNP: 10434
ClinVar: 10434
TCGA: ENSG00000120992
COSMIC: LYPLA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120992ENST00000316963O75608
ENSG00000120992ENST00000316963Q6IAQ1
ENSG00000120992ENST00000343231O75608
ENSG00000120992ENST00000518546E5RGR0
ENSG00000120992ENST00000521352E5RJ48
ENSG00000120992ENST00000521898E5RI35
ENSG00000120992ENST00000522007E5RFT6
ENSG00000120992ENST00000618741A0A087X1K9
ENSG00000120992ENST00000618914B4DP64

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
eNOS activationREACTOMER-HSA-203615

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194659242009A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.224
204188792010Small-molecule inhibition of APT1 affects Ras localization and signaling.128
233969702013Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.33
206858722010Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium.28
258499162015Enzymatic protein depalmitoylation by acyl protein thioesterases.18
194391932009Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.14
293623702018Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes.11
256706282015miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.6
292959572018The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.2
304311032019Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1.2

Citation

Dessen P

LYPLA1 (lysophospholipase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53380/lypla1