LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1)

2003-05-01  

Identity

HGNC
LYVE1
LOCATION
11p15.4
LOCUSID
10894
ALIAS
CRSBP-1,HAR,LYVE-1,XLKD1

Other Information

Locus ID:

NCBI: 10894
MIM: 605702
HGNC: 14687
Ensembl: ENSG00000133800

Variants:

dbSNP: 10894
ClinVar: 10894
TCGA: ENSG00000133800
COSMIC: LYVE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133800ENST00000256178Q9Y5Y7
ENSG00000133800ENST00000256178B2R672
ENSG00000133800ENST00000438354E7EPC7
ENSG00000133800ENST00000529598F2Z296

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan uptake and degradationREACTOMER-HSA-2160916

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
170879382006A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis.101
117194312001LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.91
178848202007Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1.45
262402912015Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.39
285046982017Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1.34
216600432011Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma.28
268234602016Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization.26
190334462009A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium.25
232645962013Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1.24
186897062008The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages.23

Citation

Dessen P

LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42844/lyve1