LZTFL1 (leucine zipper transcription factor like 1)

2010-05-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
BBS17

Other Information

Locus ID:

NCBI: 54585
MIM: 606568
HGNC: 6741
Ensembl: ENSG00000163818

Variants:

dbSNP: 54585
ClinVar: 54585
TCGA: ENSG00000163818
COSMIC: LZTFL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163818ENST00000296135Q9NQ48
ENSG00000163818ENST00000411866F8WB22
ENSG00000163818ENST00000418700F2Z2E6
ENSG00000163818ENST00000440576H7C488
ENSG00000163818ENST00000445698C9J0R9
ENSG00000163818ENST00000448111F2Z2E6
ENSG00000163818ENST00000536047Q9NQ48
ENSG00000163818ENST00000539217Q9NQ48

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369662542023LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway.1
375786432023Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects.0
369662542023LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway.1
375786432023Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects.0
349982412022CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1.8
357536022022Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19.8
349982412022CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1.8
357536022022Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19.8
342524872021lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.13
347374272021Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.67
342524872021lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.13
347374272021Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.67
325683872020Limited time window for retinal gene therapy in a preclinical model of ciliopathy.7
325683872020Limited time window for retinal gene therapy in a preclinical model of ciliopathy.7
313514502019microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1.119

Citation

Dessen P

LZTFL1 (leucine zipper transcription factor like 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51493/lztfl1