LZTFL1 (leucine zipper transcription factor like 1)

2010-05-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
BBS17

Other Information

Locus ID:

NCBI: 54585
MIM: 606568
HGNC: 6741
Ensembl: ENSG00000163818

Variants:

dbSNP: 54585
ClinVar: 54585
TCGA: ENSG00000163818
COSMIC: LZTFL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163818ENST00000296135Q9NQ48
ENSG00000163818ENST00000411866F8WB22
ENSG00000163818ENST00000418700F2Z2E6
ENSG00000163818ENST00000440576H7C488
ENSG00000163818ENST00000445698C9J0R9
ENSG00000163818ENST00000448111F2Z2E6
ENSG00000163818ENST00000536047Q9NQ48
ENSG00000163818ENST00000539217Q9NQ48

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220729862011A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.80
225104442012Exome sequencing identifies mutations in LZTFL1, a BBSome and smoothened trafficking regulator, in a family with Bardet--Biedl syndrome with situs inversus and insertional polydactyly.46
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
250057852014LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin.13
202338712010Tumor-suppressive functions of leucine zipper transcription factor-like 1.12
263646042016LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells.12
236923852014Mesoaxial polydactyly is a major feature in Bardet-Biedl syndrome patients with LZTFL1 (BBS17) mutations.10
313514502019microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1.6
267007662016LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production.5

Citation

Dessen P

LZTFL1 (leucine zipper transcription factor like 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51493/lztfl1