LZTS2 (leucine zipper tumor suppressor 2)

2004-04-01  

Identity

HGNC
LZTS2
LOCATION
10q24.31
LOCUSID
84445
ALIAS
LAPSER1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84445
MIM: 610454
HGNC: 29381
Ensembl: ENSG00000107816

Variants:

dbSNP: 84445
ClinVar: 84445
TCGA: ENSG00000107816
COSMIC: LZTS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107816ENST00000370220Q9BRK4
ENSG00000107816ENST00000370223Q9BRK4
ENSG00000107816ENST00000426584B1AL13
ENSG00000107816ENST00000429732B1AL11
ENSG00000107816ENST00000454422B1AL12
ENSG00000107816ENST00000481129S4R3W7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
170007602006LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.23
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
184903572008LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing.13
179509432008Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells.10
232753402013Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.10
294099732018LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.6
237611302013Leucine zipper tumor suppressor 2 inhibits cell proliferation and regulates Lef/Tcf-dependent transcription through Akt/GSK3β signaling pathway in lung cancer.1
294996992018LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma.1

Citation

Dessen P

LZTS2 (leucine zipper tumor suppressor 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41223/lzts2